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This translocation of the luminal contents into the lamina propria persistently stimulates the immune system leading to its hyper-activation and eventual damage to the intestine

It's the, the white picket fences with the big

PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice

This is an interesting finding, as it indicates that changes in lipid metabolism are occurring in the occipital cortex, although this is a brain region which is spared in PD, including the absence of Lewy bodies