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Another explanation could be that these adducts may break into lactone and the substrates (for example, secondary amines) of former Micheal-type addition reaction, due to the reversibility of this type of reaction (Lawrence et al., 2001)

Computing was supported via the Advanced Research Computing facility, Oxford, the ARCHER UK National Supercomputing Service and JADE (EP/T022205/1) granted via the High-End Computing Consortium for Biomolecular Simulation, (HECBioSim - supported by EPSRC (EP/R029407/1) to P.C.B