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The correlation between the expression level of CHAC1 and endoplasmic reticulum stress is known, but the connection between CHAC1, endoplasmic reticulum stress, and ferroptosis has not been extensively researched

23 In an in vitro study on human prostate carcinoma LnCaP cells, TQ decreased cell viability and enhanced apoptosis by activating caspase-9

Bentley-HewittKLChenRKYLillREHedderleyDIHerathTDMatichAJet alConsumption of selenium-enriched broccoli increases cytokine production in human peripheral blood mononuclear cells stimulated ex vivo, a preliminary human intervention study

Importantly, although several chemically-distinct agents, including glutamate, erastin, sulfasalazine and BSO, can all induce ferroptosis through GSH depletion, the present study extends our previous work by demonstrating that these diverse upstream perturbations converge on a shared downstream signaling axis centered on PDI