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Additional evidence for stress comes from proteomic studies of Bruchs membrane tissue from AMD donors, revealing the presence of oxidative products (Yuan et al., 2010), and the AREDS studies, which have shown an association between reduced prevalence of AMD and high dietary intake of antioxidants ( in vitro and in vivo studies examining AMD-vulnerable cells and tissues, which we will further review below (Figure 2)

HGSOC cells counteract chemotherapy-induced DNA damage by activating alternative DNA repair mechanisms ( When these cells experience DNA damage, they cannot repair it through the HRR pathway, leading to cell death ( However, as treatment progresses, tumor cells may acquire drug resistance through various mechanisms