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In bleomycin-induced rat models, Res inhibited miR-21 by downregulating c-Jun and c-Fos, blocking the MAPKs/AP-1 pathway ( 3.2.4 Terpenoids Triptolide, a bioactive diterpene from Tripterygium wilfordii , was shown to downregulate mRNA and protein expression of -SMA, type I collagen, FN, and vimentin, inhibiting lung fibroblast migration and transformation

This finding aligns with our observation in humans, where serum HMB concentrations were positively correlated with the fecal abundance of Lactobacillus (Fig

An in vivo study showed that baicalein inhibited metastasis in the xenograft nude mouse model