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In a first-in-human clinical trial (NCT02491281), LNA043 was administered via intra-articular injection before total knee replacement, and results showed that LNA043 could reverse the transcriptome signature associated with osteoarthritis by promoting the expression of hyaline cartilage matrix components and anabolic signaling pathways [435]

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While these injections are not a replacement for healthy diet or physical activity, they can complement a balanced lifestyle by promoting more efficient energy use and helping the body sustain metabolism during weight management efforts