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Some studies have proposed the concept of mitochondrial lactate oxidation complex (mLOC), comprising mitochondrial LDH (mLDH), MCT1, and CD147, which may mediate the direct entry of lactate into mitochondria for subsequent utilization

10.1016/j.semcancer.2019.01.005 Seminars in Cancer Biology 18 ChengJ

demonstrated that Erysipelotrichia and Paenibacillus decreased mucus permeability, whereas Proteobacteria and Saccharibacteria increased it, highlighting that mucus properties are strongly influenced by microbiota composition (60)

If lifestyle measures are insufficient , your GP may recommend: Osmotic laxatives (such as macrogol) are often recommended as first-line treatment for chronic constipation Bulk-forming laxatives (such as ispaghula husk) may be suitable when stools are small and hard, particularly with IBS-like symptoms Stimulant laxatives (such as senna or bisacodyl) for short-term use in resistant cases According to NICE Clinical Knowledge Summaries , laxatives should be used appropriately and reviewed regularly