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[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Cassidy P

It is proposed that the dimeric KEAP1 captures NRF2 first through the ETGE motif, which has 100-fold more affinity to KEAP1, followed by DLG motif docking onto the other Kelch repeat domain

52,53 In DFU, the increasing expression of IL-6 results in a sharp increase in phosphorylated STAT3 levels, 54 which mediates impaired immune cell activation, recruitment, and survival, resulting in delayed wound healing