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Psychoneuroendocrinology 64 , 150163 (2016)

Human skin, for example, has proteases that could chew up peptide bonds if they entered the solution

This assumption is reinforced by the observation that N-acetyl-L-cysteine (NAC, an antioxidant thiol and a precursor for L-cysteine, the rate-limiting amino acid in the biosynthesis of glutathione [14, 17, 112]) imposes a reducing environment, thereby protracting HIF-1 stability in the cytosol and subsequently favoring its translocation and activation [13, 14, 53, 54, 82, 111]

Current investigations continue to assess how peptide-based compounds interact within multi-pathway signaling environments, including potential influences on circadian regulation, antioxidant-associated processes, and system-level biological responses in controlled laboratory models