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Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

This supports the thyroid-gut axis ( Thyroidgut axis 2020 ), which involves significant health connections between the gut integrity and function of the gut mcirobiome and it's imapct on thyroid function

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Findings from other models of CNS degeneration, suggesting that normalization of the NADH/NAD + ratio promotes viability, support that this ratio (which is also a proxy for LPR) represents the connection between metabolic and inflammatory processes after injury [68, 69]