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While oxaliplatin induced repetitive action potential discharges in myelinated axons when electrically stimulated at 20C, gene ablation of Na v 1.6 did not evoke such action potential burst upon electric stimulation at the same temperature after oxaliplatin treatment, demonstrating that the induction of cold allodynia by oxaliplatin required Na v 1.6 (Sittl et al., 2012)

However, vitamin supplementation (folic acid, vitamin B 6 and vitamin B 12 ) is generally effective in reducing homocysteine concentrations

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