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Inflammatory mediators, such as cytokines, regulate the function of the pineal gland, leading to the suppression (i.e., secretion of proinflammatory cytokines) or potentiation (i.e., secretion of glucocorticoids) of melatonin synthesis [67]

The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis

Within the first week, many patients report a reduction in the background level of discomfort from chronic injuries

Neuroprotection means defending neurons against damage from oxidative stress, inflammation, excitotoxicity, and other threats