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It also suppresses NF-B and JAK2/STAT3 signaling, reducing IL-6 and other pro-inflammatory cytokines (Zhu et al., 2024)

2009;297:H1829H1836

Notably, each individual mutant exhibited a comparable phenotype, characterized by an approximate 12-fold reduction in survival, while still maintaining a residual ability to endure H 2 O 2 exposure

Through the reduction of mRNA and protein expression levels of NLRP3, ASC, GSDMD, and caspase 1, as well as the reduction of serum and ovarian levels of IL-18 and IL-1, moxibustion therapy, when administered to a rat model of CP-induced POF, demonstrated a significant suppression of NLRP3 activation (Yin et al