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Excess nicotinamide is eliminated partly through a methylation pathway, meaning it consumes methyl donors in the process of excretion

Zoomed view of the BID crude analytical HPLC chromatogram, emphasizing the desired product peak and the neighboring impurity peaks

The epidemiological data on sex differences in acetaminophen-induced liver injury in humans is inconsistent, which can be attributed to confounding factors such as variations in age, dosage, time elapsed from ingestion to hospitalization, and time from ingestion to N-acetylcysteine administration