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For the FFPE samples, DNA was extracted using the QIAamp DNA FFPE Tissue kit (Sigma-Aldrich) following the manufacturer's protocol

As such, no multiple testing correction was performed

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The mitochondria-targeted antioxidant Mitoquinone (MitoQ), which can traverse the inner mitochondrial membrane to directly reduce ROS, has recently garnered significant attention (Smith and Murphy 2010)