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Although a huge number of experimental and preclinical investigations have provided encouraging results, clinical trials must be performed and completed to definitely evaluate the usefulness and risks of targeting IGF-1R as an option in cancer treatment of humans

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However, unfortunately, although in vitro and in vivo experiments have clarified Fer-1s protective effect on the DR retina and its ferroptosis-regulating mechanism, corroborating the clinical potential of ferroptosis-targeted intervention, critical limitations remain in its targeting specificity, potential off-target risks and clinical translational potential of preclinical models

Growth hormone secretagogues (GHRPs) like CJC-1295, Ipamorelin, and Tesamorelin offer another promising pathway to fat loss by stimulating growth hormone release