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Shock 23 , 197 (2005)

Co-incidence of elevated IL-6 and lower GSH levels was previously reported (Valles et al., 2013), while obesogenic diets were shown to induce both of these effects in mice (Han et al., 2017) and rats (Govindaraj and Sorimuthu Pillai, 2015)

In the TME, despite various ammonia clearance mechanisms, rapidly proliferating cells, particularly tumor and immune effector cells, have a heightened demand for -KG derived from glutamine breakdown to fuel the TCA cycle, leading to substantial free ammonia production (103)

Alcohol administration in mice in the NIAAA model resulted in a significant reduction in the genus Akkermansia [191] and oral administration of Akkermansia muciphila in the Lieber-DeCarli model ameliorated features of ALD [192]