Second, cell-type and stone-subtype heterogeneity is largely ignored: current studies have focused solely on HK-2 cells, while the role of ferroptosis in other renal resident cells (e.g., renal interstitial cells and collecting duct cells) or infiltrating immune cells during stone formation is unknown

PT, a methoxylated analog of resveratrol, exhibits pleiotropic pharmacological activities including anti-cancer, neuroprotective, anti-obesity, anti-diabetic and anxiolytic activities ( Compared with retinoids, PT displays equivalent procollagen I restoration yet superior suppression of mitochondrial ROS without provoking erythema, desquamation, or photosensitivity ( Malfunctioning mitochondria can lead to a wide range of cellular problems, including increased oxidative stress and impaired energy metabolism ( Mitochondrial dynamics, biogenesis, and mitophagy are crucial processes that coordinate to maintain mitochondrial homeostasis and restore damaged mitochondrial function ( Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors

EGCG does not affect the ABC transporter in glioma CSCs but is able to downregulate P-glycoprotein, thus reducing colony formation and the migration of tumour cells [146]
Glutathione is a powerful antioxidant that helps protect cells from oxidative stressa factor implicated in the aging of skin and hair follicles