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In a state of elevated DA or increased DA oxidation exemplified by chronic or repeated administration of APDs, higher level of DA is toxic to mitochondria of neural cells in the brain (202)

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1 H NMR (400 MHz, D 2 O, ppm): = 4.674.57 (m, 1H), 3.98 (s, 2H), 3.90 (t, J = 6.4 Hz, 1H), 3.813.72 (m, 1H), 3.273.14 (m, 1H), 3.102.91 (m, 2H), 2.852.74 (m, 1H), 2.602.45 (m, 2H), 2.252.11 (m, 2H)

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