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For instance, targeting specific receptors abundantly expressed in auditory thalamocortical circuits, such as muscarinic receptors, has been proposed as a potential therapeutic strategy for hearing loss and tinnitus (Sharma et al., 2025)

Notably, most of these therapeutic agents are administered as topical formulations, a critical aspect considering patient compliance and drug delivery efficiency

Maintain a healthy weight, exercise regularly, and avoid foods high in purines like red meat and seafood