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E N D Presentation Transcript PHASE II DRUG METABOLISM: Glucuronidation and Sulfation General properties of Phase II metabolism Introduction to glucuronidation Substrates for UGTs UGT structure Properties of glucuronides Methods to characterize glucuronides Disposition and reactions of glucuronides UGT pharmacogenetics, polymorphism, variability Sulfotransferases N-Acetylation, Aminoacid conjugation, Glutathione conjugation Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Recommended Reading: Gonzales and Tukey, Drug Metabolism, In: Goodman and Gilmans, The Pharmacological Basis of Therapeutics, 11th Edition, 2005, Chapter 3

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Treatment with 5FU resulted in the reorganization of mitochondrial networks into filamentous structures (Fig