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Only R-LA is endogenously synthesized, so this isomer is essential for biological systems [27]

While some patients tolerate products well when appropriately selected, safety depends on skin sensitivity, product formulation, current routine, and clinical judgment

Additionally, linking of ring B at position 2 causes the classification of flavonoids into several groups, including flavones (such as luteolin and apigenin), flavonols (such as quercetin, myricetin, and kaempferol), flavanones (such as naringenin and hesperetin), and flavan-3-ols (such as catechin and epicatechin) (Ignat et al., 2011)

Western blotting was performed using a -4HNE antibody specific to the Michael protein adduct (EMD Millipore Corp.) at a dilution of 1:1000 antibody over night at 4C