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Elevated NNMT activity has been associated with obesity, insulin resistance, and reduced metabolic efficiency

For GLP-1 medications, clinical evidence shows that a significant proportion of patients do regain weight after stopping treatment, because the biological hunger signals that were being suppressed return

Inhibition of this enzyme can lead to pellagra, which, in these cases, may present with cerebellar signs, myoclonus, and ataxia (55)

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