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Men in this category often include those who are overweight or obese, since adipose tissue converts testosterone to estradiol via aromatase, increasing the estrogenic inhibitory signal at the hypothalamus

Indeed, in both studies, the highest frequency of TEAEs was in the normal function groups, possibly owing to the smaller sample sizes in the more severe impairment groups, or alternatively because participants with more serious health concerns, such as those with severe renal or hepatic impairment, may be less likely to notice or report mild or moderate TEAEs, as observed in populations with cancer [21]