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The islands included 2 types of cells: neuroendocrine cells, which have a less-differentiated, primitive appearance and rather scant non-distinct cytoplasm, and large epithelioid cells, which have a more complex, differentiated appearance

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When adjusted for other factors (nevi, sunburns, skin type), those with a high freckle density had an odds ratio of 6.0 for developing melanoma compared with those without freckles

Furthermore, RGTTCRA-tRFs complementarity to ribosomal RNA and the translation-supporting LeuCAG3-tRF might aggravate PD via translational inhibition, as reflected by disrupted ribosomal association of RGTTCRA-tRFs in depolarized neuroblastoma cells