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Accordingly, a marginal alteration in the intracellular concentration of GSH may not influence the catalytic activities of seleno-GPxs under in vivo conditions

For example, the cleavage site may be too close to ordered structure in the target protein." The problem is especially severe for oligomeric proteins

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Mol Neurobiol Molecular Neurobiology 2012).RemarkabIy, Dihexa completely restores performance in the rope hang test in 6-OHDA lesioned rats after two weeks treatments when delivered by the intraperitoneal route (Figure 48)