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Clin Immunol Immunopathol 80: 283289 Hurwitz BE, Klimas NG, Llabre MM, Maher KJ, Skyler JS, Bilsker MS, McPhersonBaker S, Lawrence PJ, Laperriere AR, Greeson JM et al (2004) HIV, metabolic syndrome X, inflammation, oxidative stress, and coronary heart disease risk : role of protease inhibitor exposure

Primary active transporters such as the adenosine triphosphate (ATP)-binding cassette (ABC) transporters and ion pumps (ATPases) efflux solutes from the cell or into the organelles against their concentration gradient utilizing the energy of the hydrolytic reaction of ATP (43, 44)

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Most true peptides are not orally bioavailable because stomach acid and digestive enzymes break down amino acid chains before they reach systemic circulation