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Furthermore, OS impairs P clearance by disrupting hepatic P metabolism ( 5.2.3 Aberrant angiogenesis in endometrium Endometrial angiogenesis in the menstrual cycle is a well-organized process where physiological ROS facilitate vascular formation and maturation while supraphysiological ROS concentrations induce pathological processes leading to angiogenic dysfunction ( A large amount of evidence has shown that the expression of Vascular endothelial growth factor (VEGF) is regulated by the level of ROS (72)

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