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Credit: Abriah Wofford A locking mechanism on the flip cap prevents it from popping open unexpectedly

Treating with folic acid alone can mask B12 deficiency and potentially worsen neurological outcomes

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Abbreviations AD: Autoimmune disease anti-dsDNA: Anti-double-stranded DNA AUC: The receiver-operating characteristic curve C3: Complement 3 CIMT: C arotid intima-media thickness F/B: Firmicutes/Bacteroidetes FFA: Free fatty acid FMT: Fecal microbiota transplantation HDL: High-density lipoprotein IL: Interleukins IFN: Interferon JAK: Janus kinase LCMS: Liquid chromatography-mass spectrometry LN: Lupus nephritis LDL: Low density lipoprotein ML: Machine learning RF: Random forest SLE: Systemic lupus erythematosus SLEDAI: SLE disease activity index SCFAs: Short chain fatty acids TLR: Toll-like receptor VLDL: Very low density lipoprotein KYN: Kynurenine QA: Quinolinic acid TRP: Tryptophan Tfh: T follicular helper cells Tfr: T follicular regulatory cells Treg: Regulatory T cells Th17: T helper 17 cells 4-OI: 4-Octyl itaconate NAC: N-acetylcysteine hUC-MSCs: Human umbilical cord mesenchymal stem cells References Siegel CH, Sammaritano LR