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Holt Law: For Healthcare Businesses frequently warns about the risks of marketing these compounds as dietary supplements

He C, Li L, Guan X, Xiong L, Miao X

First, the complex formed following covalent modification of -syn by 4-HNE (4-HNE/ -syn) tends to form more oligomers and fibrils than the simple -syn, subsequently forming amyloid fibers that increase the toxicity to dopaminergic neurons [61, 82]