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Some other enzymes, such as GST, -glutamyl-transferase (GGT), and alkaline phosphatase (ALP), released from proximal and distal tubule cells into urine relate to early damage

For example, zinc and selenium are essential minerals for immune cell function

Figure 3 As mentioned previously, GSH, a tripeptide containing glutamate, cysteine and glycine, (L--glutamyl-L-cysteinyl-glycine) is the master and most potent cellular antioxidant and the most abundant low molecular weight thiol that plays a crucial role in antioxidant defense against cellular ROS/reactive nitrogen species (RNS)-mediated oxidative damage and in the regulation of numerous metabolic pathways essential for maintaining whole body homeostasis

It is possible that the LKB1/AMPK/ACC pathway is activated by direct redox modulation of cellular proteins since activation of AMPK pathway has been directly linked to cellular redox status and hydrogen peroxide 49