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Each daily injection layers on top of the previous, so plasma levels build through the 10-day window and tail off after the last dose

We identify an opportunity to look beyond maintenance therapies and to consider alternative models of pharmacotherapy that support the initiation and maintenance of abstinence

To verify the ability of p16 DTRtdTomato mice to track and remove senescent cells in vivo, we obtained single-cell suspensions of the skin from aged transgenic mice treated with diphtheria toxin and analyzed with flow cytometry and immunofluorescence (Fig

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