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Ethics approval All animal studies were approved by the Institutional Animal Care and Use Committee of Augusta University (Animal Use Protocol #20170868) and were conducted in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals

Both the low expression of Keap1 and the overexpression of Nrf2 led to a significant increase in xCT mRNA levels (up to a 5-fold increase), which subsequently reduced ROS formation

77 Overexpression of HSP60 in animal models alleviates fat accumulation and improves mitochondrial function, underscoring its therapeutic potential

The livers detoxification process is complex, but most simply is divided into two steps, aptly named Phase 1 and Phase 2