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Homer Ia is rapidly induced in spinal neurons after peripheral injury in an NMDA receptordependent manner [121]

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In the brain, in order to induce tau phosphorylation, oxidative stress can directly interact with protein kinases, particularly glycogen synthase kinase-3 (GSK 3), increasing GSK-3 activity, which subsequently further disrupts its ability to bind to microtubules, accelerating their depolymerisation and interrupting neural signalling (48)

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