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In a 24-week open-label Phase I/II clinical trial (Clinicaltrials.gov Identifier: NCT00779194) in patients with active SLE, sirolimus treatment increased the proportion of circulating Foxp3+ Tregs, suppressed IL-17 and IL-4 secretion, and facilitated glucocorticoid tapering (mean prednisolone dose reduced from 23.7 mg to 7.2 mg daily) (236)

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10.1007/978-3-319-30567-7_3 7 BibiR.JahanS.AfsarT.AlmajwalA.HammadehM

Critical Interpretation Accumulating evidence underscores the diverse neuromodulatory effects of N-acetylcysteine (NAC), with substantial preclinical findings affirming its role in regulating oxidative stress, neuroinflammation, neurotransmission, and neuronal viability