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It has been shown in vitro that reactive astrocytes derived from EAE model animals and treated with fingolimod have reduced and increased production of pro-inflammatory factors and neurotrophic factors, respectively (114, 122)

REL-1017 (esmethadone) as adjunctive treatment in patients with major depressive disorder: a phase 2a randomized double-blind trial

Safety analyses from the phase 3 ASCENT trial of sacituzumab govitecan in metastatic triple-negative breast cancer

Conversely, men may be underdiagnosed until more advanced neurological or cardiovascular manifestations occur, suggesting that under-screening contributes to delayed recognition