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Although studies directly investigating the effects of PQQ on microbiota composition or function are sparse, a current supposition is that some gut bacteria may require PQQ for optimal function

[4] Moreover, research points to a possible interaction between DSIP and opioid receptors in the brain, which may play a role in the peptides ability to regulate sleep and mitigate withdrawal symptoms, underscoring its intricate role in neural signaling pathways

doi: 10.3389/fimmu.2024.1432018 Received 13 May 2024 Accepted 27 August 2024 Published 13 September 2024 Volume 15 - 2024 Edited by Frederik Denorme, Washington University in St