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The mature HGF protein binds to its high-affinity receptor c-MET, leading to its activation and phosphorylation of multiple serine and tyrosine residue sites

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A meta-analysis that included nine studies of EPA/DHA in dogs with various skin diseases found consistent reductions in itchiness, inflammation, and secondary skin problems (redness, hair loss, rash) after at least two months of treatment with EPA (daily doses ranging from 16 to 88.5 mg/kg body weight) plus DHA (daily dosages ranging from 10 to 91 mg/kg body weight)