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It is formulated with Vitamin B12, which helps produce red blood cells and maintain a healthy nervous system

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Mechanistic work shows it counters oxidative stress by boosting superoxide dismutase and catalase activities

In some embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increases intracellular NAD+ levels to provide muscular therapy