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doi: 10.1016/j.neuron.2010.06.024 41 VladimirVLupashinMGW

Given that the resultant flux distributions can exhibit sample-dependent variability, further criteria were applied to prioritize metabolic reactions that exhibit a predictable and consistent relationship between flux magnitude and phenotypic based on the following formula: Here, SHAP i represents the SHAP values across all samples ( i ) for the reaction with non-zero SHAP value and R is the squared Pearson correlation coefficient between the reactions flux values and its corresponding SHAP values across all samples, measuring the linearity and consistency of the reactions impact on the prediction

This contributes to its effects on pain as well as its side effects

Takashima T, Sakata Y, Iwakiri R, Shiraishi R, Oda Y, Inoue N