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Withdraw the needle and apply light pressure with a clean swab

For ligaments, there may be a honeymoon period of 1-2 weeks where loose ligaments are swollen and as such, provide better stability during that time, but then the initial swelling goes away and the pain and instability comes back (2)

Some researchers attempt to salvage marginally exposed vials by immediately returning them to 28C and using them within 7 days rather than the standard 28-day window, but this creates uncertainty in downstream data

In addition, compartmental or PBPK-based modeling may improve the interpretation of nanocarrier distribution, particularly for systems with formulation-dependent or nonlinear pharmacokinetics (Yuan et al., 2019