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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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Finally, for the production of OH, except during abnormal exposure to ionization radiation, generation of OH in vivo requires the presence of trace amount of H 2 O 2 and Fe 2+ salt forms OH, as given following Fenton reaction: [ 2 ] Reactive oxygen species can attack vital cell components like polyunsaturated fatty acids, proteins, and nucleic acids