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Brain-muscle loop in the fragility of older persons: from pathophysiology to new organizing models

However, bottlenecks such as immunosenescence and target heterogeneity still need to be overcome

Mechanistically, distinct PL metabolites or mediators function as membrane organizers [6], intracellular signaling regulators [13], second messengers, or enzyme activators [8, 14, 15], and participate in various cellular processes, such as epigenetic activation, signaling transduction, and metabolic adaptation [16,17,18,19]

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