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Prospective randomized trials of lowering homocysteine levels with supplements of folic acid, vitamin B 12 , and vitamin B 6 against placebo over a 5-year period in patients with vascular disease or diabetes have not, however, shown a reduction of first event fatal or nonfatal myocardial infarction, nor have these supplements reduced the risk of recurrent cardiovascular disease after an acute myocardial infarct

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