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Important in this context is the recent development of drug, a small TAT-TrkB peptide, that prevented TrkB-FL cleavage, improved cognitive performance, ameliorated synaptic plasticity deficits and prevented Tau pathology progression in vivo in a mouse model of AD [233]

A solution of TPE-CHO (180 mg, 0.5 mmol) and malononitrile (66 mg, 1 mmol) in dry EtOH (10 mL) was refluxed under nitrogen for 24 h

The occurrence of several oxidation states of metal ions (Mn) gives these metal complexes broad radical-scavenging capabilities