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While B12 directly addresses absorption issues created by tirzepatide effects on the GI tract, glycine provides theoretical muscle preservation benefits

Beyond its hypnotic effect, the DSIP DSIP exhibits documented pleiotropic properties: analgesic action via modulation of endogenous opioid pathways, anti-stress effects through the reduction of cortisol and ACTH, antioxidant and neuroprotective properties, and modulation of tolerance to ethanol and addictive substances

Jadi PK et al (2021) Alternative therapeutic interventions: antimicrobial peptides and small molecules to treat microbial keratitis