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Furthermore, we observed no significant effect on mtDNA copy number in the knockout or treatment, consistent with unchanged MIC60 expression levels, which is known to play a role in nucleoid organization (Fig

4th edition, pp

For instance, the GPx2 promoter contains so-called antioxidant response elements that confer sensitivity to oxidative stress via the Nrf2/Kelch-like ECH-associated protein 1 (Keap1) system (Banning et al., 2005)