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Another promising approach involves combining ICIs with agents that modulate the tumor microenvironment, including angiogenesis inhibitors (such as bevacizumab) and drugs targeting immunosuppressive myeloid cells [such as colony-stimulating factor 1 receptor inhibitors (CSF1R)] (145)

Ahmad et al., 2017)

Kashin-Beck disease Kashin-Beck disease (KBD) is an endemic condition that affects an estimated 2.5 million people in Tibet, northern and central China, North Korea, and southeastern Siberia, a region of Russia (58)