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Even in the absence of a psychiatric diagnosis, elevated UA levels have been associated with specific manic traits such as impulsivity, irritability, increased drive, disinhibition, and hyperthymia [97, 103, 104]

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Thus, in order to resolve the principle behind cuprizones adverse effect, and muscle disability in particular, we argue for a direct demonstration of the healing and the recovered functionality of the severely injured muscles by trauma injury [43,44,45,46,47,48] or otherwise [10,20,21,26,28,29,51,54,55,66,71,72,73,74,75,76,77,78,79,80,81,82,102,103,104], combined with the healing of the severely injured nerves [146,147,148]

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