doi: 10.15850/amj.v3n3.474 15 SmolenJSLandewRBMBijlsmaJWJBurmesterGRDougadosMKerschbaumerAet al
5.4 Effects of Se supplementation on semen quality The effects of Se supplementation therapy on semen parameters have been modestly investigated over the last 35 years and are shown in Table 4
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In Canada, advice from the British Columbia Medical Association outlines that 1 mg daily oral CN-Cbl should be used for pernicious anemia or food-bound cobalamin malabsorption (FBCM) whereas in most other cases, a daily dose of 250 g may be used ( In Netherlands, controversy arose when the Dutch Organization of General Practitioners published a 2014 viewpoint that 1 mg daily oral OH-Cbl can be utilised as treatment in cases with a cobalamin count below 148 pmol/L and clinical symptoms, with the Dutch B12 Society disputing the efficacy of this and insisting that the advice from the Dutch Healthcare Institute Pharmacotherapeutic Compass should be followed instead (IM/SC starting dose of 10 injections of 1 mg OH-Cbl at intervals of at least 3 days
